Identifying post-translational modifications (PTMs) in proteins can be very challenging, but it’s also key to understanding and treating disease. To address challenges, researchers have come up with a new strategy for data analysis they are calling “iterative search for identifying PTMs” (ISPTM). Through enabling in-depth studies of proteins, ISPTM has tremendous potential for discovering new drug targets, overcoming drug resistance in existing drug targets, and developing better therapeutic approaches.