Powerful computational platforms are enabling scientists to identify, analyze, and compare the fundamental biological components and processes that regulate human diseases and their impacts. Traditional evidence-based medicine, where testing and prescription follow personal testimony, is a one-size-fits-all approach that will one day be replaced by predictive, ongoing, numerical statements of health. Advances in modeling and simulation also play a key role in improved patient outcomes. Read about computational medicine and the shifts — from reactive to predictive — taking place in healthcare.