iSGTW - International Science Grid This Week
iSGTW - International Science Grid This Week

Home > iSGTW 26 November 2008

Issue 102: iSGTW 26 November 2008

 Fight AIDS at home, via unused computer time

Starting on World AIDS Day on 1 December, the World Community Grid will sponsor a month-long challenge via its FightAIDS@home project, with the goal of increasing the number of computers and computer cycles available to researchers conducting HIV/AIDS research.

Like all molecules, HIV—the virus that causes AIDS—is dependent upon its three-dimensional shape to attack the human immune system, in much the same way that a key must fit into a lock in order to gain entry. If the lock can be blocked—with a drug, for example—then the key cannot fit, and the virus is prevented from maturing. Such blockers, known as “protease inhibitors,” are one way of avoiding the onset of AIDS.

Researchers have been able to determine by trial-and-error the shapes of a “lock” and a “key” separately, but not always for the two together. If scientists knew how a drug molecule fits inside the active site of its target, chemists could see how they could design even better blockers, more potent than existing ones.

At the laboratory of Arthur Olson in the molecular biology department at The Scripps Research Institute in La Jolla, California, computational methods are used  to identify new candidates for drugs with the right shape and chemical characteristics to block HIV. Known as “Structure-Based Drug Design,” this approach requires vast computational resources.

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Feature - Adaptive computing

 Cruise control for e-Science

As dynamic, data-driven applications become more common on the grid, it’s tougher to guarantee when any given job will run. Or finish.

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Feature - Cosmology

 Astronomers seek to create a virtual universe

With the grid and some supercomputers, researchers  would like to simulate a region of the Universe with full gas physics.

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Link of the week

/ Just how big a number is that?

We constantly hear of terms such as “GigaFLOPS” (the FLOPS part of the acronym refers to  FLoating-point Operations Per Second).

It sure sounds like a lot.

But just how big is a petaflop, really?

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Image of the week

True to life

When architects bid on a contract for a new client, a lot depends on how realistic their design looks—and how quickly they can get it in.

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 iSGTW 22 December 2010

Feature – Army of Women allies with CaBIG for online longitudinal studies

Special Announcement - iSGTW on Holiday

Video of the Week - Learn about LiDAR


NeHC launches social media

PRACE announces third Tier-0 machine

iRODS 2011 User Group Meeting

Jobs in distributed computing


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 Mark your calendar

December 2010

13-18, AGU Fall Meeting

14-16, UCC 2010

17, ICETI 2011 and ICSIT 2011

24, Abstract Submission deadline, EGI User Forum


January 2011

11, HPCS 2011 Submission Deadline

11, SPCloud 2011

22, ALENEX11

30 Jan – 3 Feb, ESCC/Internet2


February 2011

1 - 4, GlobusWorld '11

2, Lift 11

15 - 16, Cloudscape III

More calendar items . . .


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